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Since 2003, Hugo Tempelman and his team have been treating HIV patients in the Ndlovu Medical Center with the antiretroviral therapies. Although the drugs improve the immune system and make patients less susceptible to dangerous infections. They increase life expectancy and significantly improve quality of life.

An HIV vaccine is the ultimate goal for intensive research groups. In April 2016, the HIV Vaccine Trails Network contacted Dr. Hugo Tempelman. The network has developed an AIDS vaccine and now wants to start the human study after the animal testing phase.